Original Research Article
Year: 2020 | Month: October | Volume: 7 | Issue: 10 | Pages: 404-411
Association of Platelet Count/Spleen Size Ratio in Relation with Grades of Esophageal Varices and Severity of Chronic Liver Disease
Uthaya Sankar M.K1, Naveen Sathish.V2, Mythreini Satheesh3, Thirumal.P4
1Professor, 2,3Post graduate resident, 4Assistant Professor,
Department of General Medicine, Sri Manakula Vinayagar Medical College and Hospital, Puducherry-605107, India
Corresponding Author: Naveen Sathish.V
ABSTRACT
Background: Most serious complication of portal hypertension in patients with liver diseases is esophageal varices. This study was conducted to evaluate noninvasive predictors of large esophageal varices in comparison with small or absent varices in patient with cirrhosis.
Objective: To assess the association of platelet count/spleen size ratio in relation with severity of varices and to compare with Child Pugh’s score of chronic liver disease.
Methodology: A Hospital based cross section study was conducted in Department of General Medicine and Gastroenterology. The study population is of 90 who were diagnosed to have chronic liver disease based of ultrasonogram and biochemical test.
Results: Incidence of large varices was seen in 34.4%.Onmultivariate analysis, only spleen diameter is independent predictors for the presence of large varices with mean size of 14.2cm. The sensitivity of PC/SD Ratio of ≤ 909 in predicting presence of esophageal varices in our study was 61.29 and specificity was 61.02%. However, the mean PC/SD to predict the large esophageal varices in our study was ≤ 962.3 and small and absent varices was 1172.7. Although there is significant reduction in PC/SD ratio between the two groups it was not statistically significant.
Conclusion: From our study we conclude that presence of splenomegaly and lower PC/SD ratio determine the presence of higher grades of varices and can hence identify the patients who require endoscopy for the prophylactic management of esophageal varices.
Keywords: platelet count/spleen size ratio, esophageal varices, Child Pugh’s score, chronic liver disease
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