Original Research Article
Year: 2018 | Month: June | Volume: 5 | Issue: 6 | Pages: 47-52
Non Invasive Biomarkers, Serum Prolidase, Fibroscan, APRI Score in Non Alcoholic Fatty Liver Disease
Dr. Jugnu Kishore1, Dr. Upendra Kumar Das2, Dr. Anuva Mishra3,
Dr. Umesh Chandra Patra4, Dr. Srikrushna Mohapatra5
1PG student, 2Associate Professor, 5Prof & HOD, Dept of Biochemistry, SCB Medical College, Cuttack
3Associate Professor, Dept of Biochemistry, MKCG Medical College, Berhampur
4Prof & HOD, Dept.Of Hepatology, SCB Medical College, Cuttack
Corresponding Author: Dr. Upendra Kumar Das
Background & objectives: NAFLD may progress from simple steatosis, non alcoholic steatohepatitis, cirrhosis & hepatocellular carcinoma. The fat content of liver is <5% & if it increases >5-10%, that shows steatosis. The spectrum is not linear, all steatosis patients may not develop NASH & cirrhosis but may show a backward direction. Two hit hypothesis is proposed for pathogenesis, where mitochondrial dysfunction with oxidative stress and activation of stellate cells lead to myofibroblast to secrete collagen. Liver biopsy is the gold standard procedure for diagnosis, due to limitations non invasive procedures have been developed, which are low cost and have easy accessibility. Serum Prolidase is used as direct marker to access the pathophysiology of fibrosis & reflect collagen turnover. Indirect markers of liver fibrosis are ratio of AST/ALT, APRI score & fibroscan. Fibroscan uses to measure tissue stiffness.
On this background the study aims at correlating non invasive markers S. Prolidase with liver function test & degree of fibrosis.
Materials & Methods: Fifty numbers of NAFLD cases & age & sex matched fifty numbers of healthy controls were chosen. BMI, FPG, lipid profile, liver function test, S.Prolidase, AST/ALT ratio, APRI score & fibroscan were measured in both groups.
Results: Serum Prolidase activity & fibroscan were significantly higher (p, 0.001) in NAFLD cases than control group. There was a significant positive correlation between S. Prolidase with fibroscan.
Conclusion: S. Prolidase may be considered as a cost effective marker for NAFLD.
Key words: NASH, NAFLD, Prolidase, APRI, Fibroscan.[PDF Full Text]