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Original Research Article

Year: 2018 | Month: June | Volume: 5 | Issue: 6 | Pages: 24-31

Comparative Evaluation of Fourth Generation Fluoroquinolones with Fortified Cephazolin in the Treatment of Bacterial Corneal Ulcers

Dr. Smita Kishor Kadu1, Dr. Nilesh Balaji Giri2, Dr. Santosh Yadawrao Ingle3, Dr. Neha Chandrashekhar Yerawar4

1Professor & Head of Department, 2Junior Resident, 3Senior Resident, Department of Ophthalmology, 4Junior Resident,
Dr. Panjabrao Deshmukh Memorial Medical College, Amravati, Maharashtra 444602

Corresponding Author: Dr. Nilesh Balaji Giri


Purpose: To study efficacy of fourth generation fluoroquinolones versus conventional fortified cephazolin eye drops for the treatment of bacterial corneal ulcers.
Method: 40 diagnosed cases of bacterial corneal ulcers were randomly allotted into two groups: Group 1 patients were treated using fortified cephazolin (50 mg/ml) and, group 2 with commercially available fourth generation fluoroquinolone-Moxifloxacin 0.5% eye drops.
The response to treatments were analyzed according to the size of corneal ulcer and anterior chamber cell reaction at second and third weeks. Also size of the residual corneal opacity was analyzed after complete healing of corneal ulcer were compared.
Data were statistically analyzed using appropriate test of significance using SPSS software (version16.0)
Results: Data was statistically analyzed using t- test. In this study, both the groups were equally matched in terms of size of the ulcer and anterior chamber cell reactions, at the time of presentation with p- values 0.85 and 0.06.
At 2 weeks after initializing the treatment, the difference in response to treatment in group 2 was statistically significantly better as compared to group 1 with p values of 0.008 and 0.0004 for corneal ulcer size and anterior chamber cell reactions, respectively. Similarly, with p< 10-6 for both at week 3 of treatment.
Comparing the size of residual corneal opacity after complete healing of the corneal ulcers in group 2 was statistically significantly smaller as compared with group 1 with p=0.0004.
Conclusion: The current study shows that treatment response of bacterial corneal ulcers with fourth generation fluoroquinolones is significantly better than conventional treatment with fortified cephazolin eye drops.

Key words: Bacterial corneal ulcer, fortified cephazolin, fluoroquinolones, moxifloxacin

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