Original Research Article
Year: 2018 | Month: June | Volume: 5 | Issue: 6 | Pages: 133-144
Study on Role of Antidepressant Drug in Antipsychotic like Effect of Clozapine in Rats
Aarti K. Thakre, Nitin G. Dumore
DadasahebBalpande College of Diploma in Pharmacy, Besa, Nagpur.
Corresponding Author: Aarti K. Thakre
Background: Clozapine is an atypical antipsychotic drug commonly used in treatment of schizophrenia. However, the exact mechanism of its action is still not clear. The present study was planned to examine the role of antidepressant in antipsychotic like effect of clozapine.
Methods: Sprague–Dawley rats weighing 220–250 g were cannulated for intra cerebroventricular (icv) drug administration and injected with artificial cerebrospinal fluid (aCSF) or clozapine (5, 10 μg/rat icv), imipramine (i.c.v.; 1-6 ug/rat) alone or their combination and evaluated for antipsychotic activity in condition avoidance response test. The results were express as % inhibition of condition avoidance response.
Results: I.C.V. administration of clozapine (10 μg/rat icv) and imipramine (i.c.v.; 6 ug/rat)showed dose dependent suppression of condition avoidance response. Imipramine potentiated antipsychotic effect of clozapine at its effective dose in CAR test.
Conclusion: This study demonstrated the participation of antidepressant drug in antipsychotic like effect of clozapine.
Key words: Antipsychotic, Cerebroventricular, Schizophrenia, Cerebrospinal fluid[PDF Full Text]