Original Research Article
Year: 2018 | Month: October | Volume: 5 | Issue: 10 | Pages: 177-188
Formulation and Evaluation of Antihistaminic Activity of Proniosome Based Transdermal Patches
Dr. Deepu. S1, Dr. M.A. Kuriachan2, Sreekavya. B3
1Associate Professor in Pharmaceutics, 2Professor in Pharmaceutics, 3Department of Pharmacy
Mar Dioscorus College of Pharmacy, Alathara, Sreekariyam, Thiruvananthapuram
KUHS University, Kerala, India.
Corresponding Author: Dr. Deepu. S
ABSTRACT
The objective of the present work was to develop transdermal patches loaded with proniosomes of Chlorpheniramine maleate to improve the bioavailability and to study the effect of different surfactants on drug release. Proniosomes were prepared using different ratios of surfactants, lecithin and cholesterol by coacervation phase separation method. Drug polymer interactions were studied using FTIR analysis. The formulated proniosomes were evaluated for their physical nature, particle size, pH, Spreadability, encapsulation efficiency and carried out in vitro study. Among all these, formulations containing span60 i.e. F2, F5, F8 shows higher encapsulation efficiency & % CDR, these were selected & converted into reservoir type transdermal patches. These patches were fabricated using backing layer & rate controlling membrane. Evaluation studies like weight variation, percentage moisture content, thickness, flatness, folding endurance, drug content, in vitro studies were carried out. The formulation TP2 showed maximum drug release of 96.42% and drug content of 98.27%. At last concluded that transdermal patch TP2 loaded with proniosome F5 was the optimum formulation.
Key words: Transdermal drug delivery, Proniosomes, Encapsulation, In vitro study
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