Case Report
Year: 2022 | Month: August | Volume: 9 | Issue: 8 | Pages: 674-677
DOI: https://doi.org/10.52403/ijrr.20220855
Seizures as a Manifestation of Isoniazid Intoxication: A Case Report
Putu Gizha Satrya Gautama M1, AAA Yuli Gayatri1
1Department of Internal Medicine, Faculty of Medicine, Universitas Udayana, Sanglah General Hospital, Bali, Indonesia
Corresponding Author: Putu Gizha Satrya Gautama M
ABSTRACT
Introduction: Isoniazid (INH) intoxication is a serious health problem that can be life-threatening. Acute intoxication manifests as neurological symptoms such as seizures.
Case Illustration: A woman, 27 years old, came to the emergency department with seizures after taking ten tablets (3000 milligrams) of Isoniazid. Laboratory examination showed a severe metabolic acidosis and increased liver function test. The management primarily consists of basic life support, antiseizure, and antidote.
Conclusion: Isoniazid toxicity is associated with a high mortality rate. The first signs and symptoms of isoniazid toxicity may appear within 30 minutes to two hours. Acute toxicity of Isoniazid may manifest as neurological symptoms such as seizures. Management of INH intoxication consists of controlling the life-threatening condition, administering an antidote such as pyridoxine, and symptomatic supportive therapy.
Keywords: Isoniazid, intoxication, seizures
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