Original Research Article
Year: 2022 | Month: May | Volume: 9 | Issue: 5 | Pages: 8-9
DOI: https://doi.org/10.52403/ijrr.20220502
Comparison of Adenosine Deaminase Activity in COPD with Healthy Subjects
Prangyada Reecha Joshi1, Prachi Goyal2, Vishal Garg3
1Department of Biochemistry, Maharaja Vinayak Global University, Jaipur, Rajasthan
2Department of Biochemistry, Maharaja Vinayak Global University, Jaipur, Rajasthan
33Faculty of Science, Maharaja Vinayak Global University, Jaipur, Rajasthan
Corresponding Author: Prachi Goyal
ABSTRACT
Background: Chronic obstructive pulmonary disease (COPD) is a disease condition characterised by non-reversible airflow restriction. Emphysema, which is the damage and inflammation of the lung alveoli, is a component of COPD. It has been demonstrated that adenosine levels rise in COPD leading to reduction in adenosine deaminase (ADA) activity. Aim: We determined the activity of ADA in COPD patients.
Methods: Sixty subjects were included in this case-control study who had an acute exacerbation of COPD. The activity of the ADA was measured in 20 COPD, 20 non-smokers, and 20 smokers who served as controls.
Results: Total ADA activity was significantly lower in the COPD and smoking control groups (17.87±6.73, 18.09±8.9, and 21.90±6.4 U/L, respectively) than in the non-smoker group.
Conclusion: Reduction in ADA activity may play an important role in the development of lung damage in COPD patients.
Keywords: Adenosine deaminase (ADA); Chronic Obstructive Pulmonary Disease (COPD), Lung.
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