Original Research Article
Year: 2022 | Month: May | Volume: 9 | Issue: 5 | Pages: 79-85
DOI: https://doi.org/10.52403/ijrr.20220514
Correlation between Ratio Leukocyte / Mean Platelet Volume (MPV) in Acute Coronary Syndrome Patients
Zaharuddin1
1Internal Medicine Department, Medical Faculty, University of North Sumatra.
Corresponding Author: Zaharuddin
ABSTRACT
Background: Acute Coronary Syndrome (ACS) is a major cardiovascular problem that has a high mortality rate and hospitalization rate. In America alone in 2020, there were more than 1,000,000 coronary heart disease sufferers. According to Riskesdas 2013, the prevalence of coronary heart disease in Indonesia (Central Java) was 0.5% or as many as 120,447 people (Kemenkes, 2013). Around 9-19% ACS causes death in the first 6 months after diagnosis and half of deaths occur within first 30 days.
Aim: To know the relationship between leukocyte ratio/mean platelet volume and GRACE score in acute coronary syndrome.
Method: This research is an analytical observational study using a cross sectional research design with consecutive sampling and using medical data from central installation patients at H.Adam Malik Hospital in the period January 2021 to Juny 2021 that meets the inclusion and exclusion criteria. The sample is calculated using the large proportion estimation formula. Then proceed with the post hoc Mann Whitney test to see which groups have differences. The magnitude of the desired deviation (α) is 0.05, statistically significant if p<0.05.
Results: 75 subjects participated in the study and there was a mean leukocyte/MPV ratio, in CAD 1021.05, STEMI 981.20, and NSTEMI 473.71. Based on the analysis carried out, a significant relationship was obtained with a p value <0.05 (p = 0.001). The mean GRACE score for CAD was 137, STEMI 125, NSTEMI 141.50. Based on the analysis carried out, a significant relationship was obtained with a p value <0.05 (p = 0.001). Conclusion: The Leukocyte/MPV ratio has a strong positive correlation with the GRACE score with an r value of 0.723 and a p value of 0.001.
Keywords: leukocyte/MPV ratio, ACS, GRACE Score.
[PDF Full Text]