Original Research Article
Year: 2022 | Month: February | Volume: 9 | Issue: 2 | Pages: 17-22
DOI: https://doi.org/10.52403/ijrr.20220204
Association of Procalcitonin Values with Mortality of Elderly Sepsis Patients
Anita Rosari Dalimunthe1, I Dewa Putu Pramantara2, Probo Suseno2
1Division of Geriatric, Department of Internal Medicine, RSUP Haji Adam Malik, Medan, Indonesia
2Division of Geriatric, Department of Internal Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/RSUP Dr. Sardjito Yogyakarta
Corresponding Author: Anita Rosari Dalimunthe
ABSTRACT
Background: Elderly is an age group that is prone to sepsis and is sometimes difficult to enforce because signs of inflammation rarely appear. Procalcitonin is a specific marker for bacterial infection in the elderly and can be a sign of the severity of sepsis and can be used as a predictor of septic death in the elderly. The purpose of this study was to determine the relationship between procalcitonin levels and mortality in elderly septic patients.
Methods: This study was an analytic observational study with a retrospective cohort design. Data were obtained from the patient's medical records. To analyze the sensitivity and specificity of procalcitonin values in sepsis patients, statistical analysis of receiver-operating characteristics (ROC) curves was used with significant results if the ROC curve value was more than 50%. To determine the procalcitonin value with outcome, Chi-square test was performed. The data was processed with SPSS version 22.0. The test results are said to be meaningful if the p value <0.05.
Results: The subjects of this study amounted to 52 people who met the inclusion and exclusion criteria. The median value of the age of the subjects was 66 (60-87) years with the most male subjects 51.92%. The diagnosis of severe sepsis was 48.08% followed by 29.62% sepsis and 25% septic shock. Subjects died as many as 27 subjects (51.92%). Hemoglobin level 11.3 g/dl; leukocytes 15.26.103/ml; platelets 150.103/ml and the value of procalcitonin 12.42 mcg/dl. The procalcitonin ROC curve showed that procalcitonin had a good predictor value (AUC 79.7%; p value 0.001), the procalcitonin value was 12.67 mcg/dl. Procalcitonin levels >12.67 mcg/dl died in 12 (75%) patients while elderly patients with procalcitonin levels <12.67 mcg/dl died in 6 (25%) patients. The chi-square test got a p value of 0.001 (RR 3 CI 95% 1.453-6.196).
Conclusion: Procalcitonin is associated with mortality in elderly septic patients
Keywords: Procalcitonin, Sepsis, elderly.
[PDF Full Text]