Review Article
Year: 2022 | Month: February | Volume: 9 | Issue: 2 | Pages: 143-155
DOI: https://doi.org/10.52403/ijrr.20220221
Timeline Approach for the Treatment of COVID-19 – An Overview
Pavani Polipilli1, Vishnu Vamsi Nannur2, Bharathi Vudi3, Sai Durga Yakkaladevara4, Yasa Sree Reemali5, J John Kirubakaran6
1-6Vikas Institute of Pharmaceutical Sciences, Nidigatla village, Korukonda Mandal, Rajahmundry, Andhra Pradesh, 533103, India.
Corresponding Author: Sai Pavani Polipilli
ABSTRACT
The outbreak of novel CORONA virus has taken many lives since the onset of the pandemic. On December 31, 2019, the World Health Organization received reports of pneumonia with an unknown aetiology in the Chinese city of Wuhan. Chinese officials discovered a new coronavirus as the source of the outbreak on 7 January 2020, provisionally named "2019-nCoV." The World Health Organisation has recorded 4,215,966 confirmed cases and 79,758 fatalities by the end of December 2020, both of which have been raised quickly. The main symptoms of this disease that were recorded so far include fever in 85% of patients, dyspnoea in 70–80%, cough in 40–80%, smell and taste dysfunction in 50%, myalgia in 30%, and gastrointestinal problems in 10–30%. To reduce the count of patients entering into severity phase many diagnostic criteria were employed that includes Reverse Transcriptase Polymerase Chain Reaction test, High Resolution Computed Tomography scan, measuring the levels of Creatinine Reactive Protein, Domain Dimer, Serum Ferritin to assess the level of inflammation. Nevertheless, of all the treatment strategies employed by various researchers, doctors, scientists, and vast number of organizations and institutions, this review article provides the treatment strategies to treat Covid-19 according to the timeline progression of the disease, gleaning the information from various sources. The treatment protocol includes the right time diagnosis and starting the treatment with remdesivir, corticosteroids, anti-platelet agents and Interleukin-6 inhibitors, Janus Kinase inhibitors basing on the severity of the disease. But the crucial part to treat Covid-19 lies in establishing the right therapy at the right time.
Keywords: Remdesivir; Corticosteroids; Anti-platelet agents; Cytokine storm; C-reactive protein; D-Dimer; Serum ferritin; RT-PCR, Janus kinase inhibitors.
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