Review Article
Year: 2021 | Month: April | Volume: 8 | Issue: 4 | Pages: 252-268
DOI: https://doi.org/10.52403/ijrr.20210433
Liposome: A Novel Drug Delivery System
Ganesh Shankar Sawant1, Kiran Vilas Sutar2, Akhil S. Kanekar3
1,2Final Year B. Pharmacy of Shree Sarasvati Institute of Pharmacy, Tondavali, Kankavali, Sindhudurg, Maharashtra.
Dr. Babasaheb Ambedkar Technological University, Lonere, Raigad, Maharashtra.
3Assistant Professor in Shree Saraswati Institute of Pharmacy, Tondavali, Kankavali, Sindhudurg, Maharashtra.
Dr. Babasaheb Ambedkar Technological University, Lonere, Raigad, Maharashtra.
Corresponding Author: Kiran Vilas Sutar
ABSTRACT
Liposome is a spherical sac phospholipid molecule. It encloses a water droplet especially as form artificially to carry drug into tissue membrane.
It is spherical sac vesicle it consists at least one lipid bilayer. Liposomes are mainly development for drug delivery size and size distribution. The process of sonication (extrusion) is required to obtain small size and narrow size distribution of liposome. The main significant role in formulating of potent drug, improve therapeutic effect. Liposome formulation is mainly design in increasing accumulation at the target site, and then resulting effect is targeted to reduce toxicity. There is various method for liposome formulation depending upon lipid drug interaction liposome disposition mechanism- parameters particle size, charge and surface hydration.
Liposome is a nanoparticle (size-100nm). Nanoscale drug delivery system using liposome as well as nanoparticle. This technology is for "Rational delivery of chemotherapeutic" drug treatment of cancer. Liposome is use as to study the cell membrane and cell organelles. The advantages of liposome formation using microfluidic approach for bulk-mixing approaches are discussed.
Keywords: liposome, lipid bilayer, sonication, nanoparticles, particle size, toxicity.
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