Original Research Article
Year: 2021 | Month: October | Volume: 8 | Issue: 10 | Pages: 440-457
DOI: https://doi.org/10.52403/ijrr.20211059
Development and Characterization of Metronidazole Loaded Microsponges for the Management of Diabetic Foot
Ponni Sujathan1, Umesh Kumar Sharma2
1,2Mar Dioscorus College of Pharmacy, Alathara, Sreekariyam, Trivandrum
Corresponding Author: Ponni Sujathan
ABSTRACT
The objective of present work was formulation and evaluation of Metronidazole loaded microsponges for the management of diabetic foot ulcer via topical application and to reduce side effects. The microsponges were prepared by quasi-emulsion solvent diffusion method using different concentrations of Ethyl cellulose and Poly vinyl alcohol. The prepared microsponges were evaluated for particle size analysis, SEM, % production yield, % drug entrapment efficiency, in-vitro drug release studies, DSC and antimicrobial studies. FTIR studies shown that there was no interaction between drug and polymers. The optimum sustained release of drug around a period of 12hrs was shown by formulation F8. The n value of optimized formulation indicated that the drug release followed zero order kinetics. It was confirmed from the stability studies that the optimized formulation remained stable at 45±2℃ and 70±5% relative humidity.
Keywords: Microsponges, Metronidazole, Diabetic Foot, Quasi-emulsion solvent diffusion, Sustained release, Scanning electron microscopy, Differential scanning calorimetry.
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