Original Research Article
Year: 2021 | Month: October | Volume: 8 | Issue: 10 | Pages: 374-382
DOI: https://doi.org/10.52403/ijrr.20211050
The Relationship between Neutrophil Lymphocyte Ratio and Platelet Lymphocyte Ratio to Degree of Activity in Systemic Lupus Erythematosus
Irsyadil Fikri1, Zuhrial Zubir2, Ananda Wibawanta Ginting2
1Department of Internal Medicine, Faculty of Medicine, Universitas Sumatera Utara
2Division of Pulmonology and Allergy-Immunology, Department of Internal Medicine, Faculty of Medicine, Universitas Sumatera Utara
Corresponding Author: Irsyadil Fikri
ABSTRACT
Background: Systemic lupus erythematosus is a chronic autoimmune inflammatory disease with a wide spectrum of clinical and serological manifestations caused by autoantibody production, complement activation, and immune complex deposition. Several studies have shown that the neutrophil-lymphocyte ratio and the platelet-lymphocyte ratio are closely correlated with systemic lupus erythematosus and its disease activity so that they can be used as diagnostic indicators and monitoring of systemic lupus erythematosus.
Objective: To determine the relationship between the ratio of neutrophil lymphocytes and the ratio of platelets to lymphocytes on the degree of activity of lupus disease in patients with systemic lupus erythematosus.
Methods: This is an observational analytic study using medical record data from central installation patients at H. Adam Malik Hospital in the period January to December 2019. The sample was calculated using the unpaired comparative sample size formula for more than two groups of one measurement. Then the distribution test was carried out with the Shapiro Wilk test. Bivariate analysis was conducted to determine the relationship between the ratio of neutrophil lymphocytes and the ratio of platelets to lymphocytes with the MEX SLEDAI score using the ANOVA test if the data were normally distributed, or the Kruskal-Wallis test if the data was not normally distributed. Then proceed with the Mann-Whitney post hoc test to see which groups have differences. The sum of deviations (α) is 0.05, statistically significant if p<0.05.
Results: 120 subjects participated in the study and 33 people (27.5%) had mild systemic lupus erythematosus, 47 (39.2%) moderate degrees, and 40 people (33.3%) severe degrees. Conclusion: The neutrophil-lymphocyte ratio and the platelet-lymphocyte ratio are associated with the degree of lupus activity in patients with systemic lupus erythematosus.
Keywords: neutrophil-lymphocyte ratio, platelet lymphocyte ratio, systemic lupus erythematosus.
[PDF Full Text]