Original Research Article
Year: 2021 | Month: October | Volume: 8 | Issue: 10 | Pages: 93-104
DOI: https://doi.org/10.52403/ijrr.20211014
Formulation and Evaluation of Floating Bioadhesive Tablet of Candesartan Cilexetil Using 32 Factorial Designs
Asish Dev1, Nihar Lohagaonkar2, Mansi Deshmukh3
1,2,3Oriental College of Pharmacy, Navi Mumbai, Maharashtra
Corresponding Author: Asish Dev
ABSTRACT
Objective: The objective of the work is to formulate candesartan cilexetil floating bioadhesive tablets which can considerably improve the bioavailability of medicine underneath the condition of redoubled continuance of drug in abdomen.
Methods: Floating bioadhesive tablet was ready by direct compression of chemical compound like HPMCE15 and Carbopol934p together.
Result: After analysis of different evaluation parameter and drug release, F4 batch was selected as promising formulation for delivery of candesartan cilexetil floating bioadhesive tablets with 91.22% drug release at 12th h.
Conclusion: Among the further batches, the F4 batch was selected as an optimized batch as a result of the pre-compression and post-compression parameters results area unit satisfactory.
Keywords: Candesartan cilexetil, Floating bioadhesive tablets, Polymer, Total floating time.
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