Original Research Article
Year: 2020 | Month: March | Volume: 7 | Issue: 3 | Pages: 512-515
Outcome Prediction for Patients with Cirrhosis of the Liver in a Tertiary Care Centre: Relation to Serum Vitamin C
Debkumar Ray1, Bholanath Maji2
1Associate Professor, 2Assistant Professor,
Biochemistry Department, Burdwan Medical College and Hospital, Burdwan, West Bengal
Corresponding Author: Bholanath Maji
ABSTRACT
There have been many studies concerning the prognostic factors in cirrhosis of liver, but without any unanimous conclusion. Nutritional factors have been shown to affect the prognosis of cirrhosis. With this background, the authors tried to assess the prognostic importance of vitamin C, if any, in cirrhosis of liver. The present study was conducted in the Department of Biochemistry of a tertiary care medical college and hospital. Serum vitamin C and INR of 91 LC patients with esophageal varices and ascites (group 1), and 78 LC patients without esophageal varices and ascites (group 2) were estimated. Vitamin C was significantly decreased and INR was highly significantly increased in group 1 with respect to group 2. Depletion of vitamin C levels in serum may be related to the progress of cirrhosis of liver, but this needs to be validated by further studies in larger number of subjects. Vitamin C may be considered as a useful biomarker of antioxidant status in cirrhosis of liver for elaboration of monitoring.
Keywords: cirrhosis of liver, vitamin C, INR, prognosis
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