Case Series
Year: 2020 | Month: March | Volume: 7 | Issue: 3 | Pages: 458-462
Antitubercular Drugs Induced Liver Injury: A Case Series & Review
Hima Bindu P1, Raksha M A1, Inayathulla K1, K Thejasvi1, Botla Devika1, Varun Lal2
1Student, 2Assistant Professor,
Department of Pharmacy Practice, TVM College of Pharmacy, Ballari, Karnataka, South India. PIN – 583103
Corresponding Author: Varun Lal
ABSTRACT
Tuberculosis (TB) is caused by tubercle bacilli, which belong to the genus Mycobacterium, namely Mycobacterium tuberculosis, Mycobacterium bovis, Mycobacterium africanum etc. Mycobacterial infections are among the most difficult of all bacterial infection to cure. Isoniazid, Rifampicin, Pyrazinamide are essential component of directly observed treatment short-course (DOTS) strategy to control TB by WHO & all the three agents is observed to cause potential hepatotoxicity. Here Causality assessment was done by using Roussel Uclaf Causality Assessment Method (RUCAM) / Council for International Organisations of Medical Sciences (CIOMS) Scale & Naranjo Algorithm. Here we have discussed four different cases of antitubercular drugs induced hepatotoxicity & also focussed on the management of the above condition.
Keywords: Tuberculosis (TB), causality assessment, anti-tubercular drugs, hepatotoxicity, Naranjo algorithm.
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