Original Research Article
Year: 2020 | Month: March | Volume: 7 | Issue: 3 | Pages: 1-7
Platelet to Lymphocyte Ratio as a Prognostic Marker in ICU Patients with Acute Kidney Injury
L Patil1, Yudhishther Kuntal2
1Professor, 23rd Year Junior Resident,
Dept. of General Medicine, Shri BM Patil Medical College and Hospital, Vijaypura, Karnataka
Corresponding Author: Yudhishther Kuntal
ABSTRACT
Inflammation plays a key role in the initiation and progression of acute kidney injury. Evidence regarding the prognostic effect of the platelet-to-lymphocyte ratio, an easily available systemic inflammation marker, among patients with acute kidney injury is less. In this study, we investigated the value of the Platelet-to-lymphocyte ratio in predicting the outcomes of Intensive care unit patients with acute kidney injury.
Methods: The study included 91 critically ill patients with acute kidney injury of Intensive care unit and Emergency ward. Informed consent was obtained from all patients. Period of study was from November 2017 to June 2019. Platelet-to-lymphocyte ratio cut-off values were determined using Receiver Operating Characteristic analysis.
Results: A total of 91 Intensive care unit patients with acute kidney injury were enrolled. A total of 24 deaths occurred,15 worsened and 52 improved. A U-shaped relationship was observed between the Platelet-to-lymphocyte ratio and prognosis at discharge, with the lowest risk being at values ranging from 100 to 299. Out of the parameters assessed, ESR, Blood urea and platelet count was significantly higher in high Platelet-to-lymphocyte ratio (>299) group. Lymphocyte counts showed significantly lower levels in the high Platelet-to-lymphocyte ratio (>299) group.
Conclusions: The preoperative Platelet-to-lymphocyte ratio was associated in a U-shaped pattern with survival among patients with acute kidney injury. The Platelet-to-lymphocyte ratio appears to be a novel, independent prognostic marker of outcomes in critically ill patients with acute kidney injury. Its clinical impact must be validated with appropriate study design and sample size.
Keywords: Platelet-to-lymphocyte ratio, acute kidney injury, prognosis, intensive care unit
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