Original Research Article
Year: 2020 | Month: February | Volume: 7 | Issue: 2 | Pages: 354-357
Acute and Repeated Oral Toxicity Studies on Siddha Drug Lavanga Choornam
Kavitha. T1, Mythili. P 2, Esaivani. S1, Susila.R1
1Research Officer (Siddha), Siddha Central Research Institute, Arumbakkam, Chennai.
2Siddha Physician, Chennai, Tamil Nadu, India
Corresponding Author: Kavitha. T
ABSTRACT
The polyherbal Siddha formulation Lavanga choornam (LC) has been indicated in classical literature for the management of “Pitha paandu noi” (Iron deficiency Anaemia). Though these age old traditional formulations have been clinically beneficial, till now no scientific data exists to confirm its safety and efficacy. Hence the present study was conducted to determine the acute and Sub acute safety profile of Lavanga choornam (LC). The Acute toxicity was carried out in 20 colony inbred animals strains of wistar rats of either sex weighing 200- 250 g and divided into control group that received distilled water and test group. The test drug Lavanga choornam (LC) was administered to the groups in a single oral dose (2000mg/kg bwt). In acute toxicity study the animals were observed for body weight and mortality for 14 days. Repeated oral toxicity study was conducted in 20 Male and Female wistar albino rats of both sexes and was divided into 2 groups (Group I- control (1% sodium carboxy methyl cellulose), Group II-500 mg of test drug). Administration was by oral gavage once a day for 28 days and the animals were observed for clinical signs, body weight, food and water intake and mortality. The study results showed that both acute and repeated oral toxicity studies did not produce toxic effects when administered 10 times of therapeutic dose and LD50 > 2000mg/kg hence indicating the safety of Lavanga choornam (LC)
Keywords: Lavanga choornam, oral toxicity, Iron deficiency Anaemia, Siddha herbal formulation, Pitha paandu.
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