Original Research Article
Year: 2020 | Month: January | Volume: 7 | Issue: 1 | Pages: 397-400
Can Serum MDA: SOD Ratio Predict Risk of Retinopathy in Type 2 Diabetes Mellitus?
Subhramay Chatterjee1, Sandip Chakraborti2
1Associate Professor, Biochemistry Department, Murshidabad Medical College and Hospital, Berhampore, West Bengal, India
2Associate Professor, Biochemistry Department, NRS Medical College and Hospital, Kolkata, West Bengal
Corresponding Author: Sandip Chakraborti
ABSTRACT
Background-Free radicals may play a role in diabetic retinopathy. Aims and objectives-Serum malondialdehyde and superoxide dismutase can be measured to assess the levels of free radicals and antioxidants respectively. In the present study we tried to find out any correlation between the ratio of serum malondialdehyde: superoxide dismutase and diabetic retinopathy.
Materials and methods- Serum malondialdehyde and superoxide dismutase were measured in 67 diabetic retinopathy cases and 61 diabetic patients without retinopathy.
Results- In cases superoxide dismutase levels were decreased significantly and malondialdehyde levels were increased highly significantly with respect to controls. The ratio superoxide dismutase: malondialdehyde in cases was decreased significantly with respect to controls.
Conclusion-A cutoff value of 0.144 for the ratio malondialdehyde: superoxide dismutase in serum of diabetic patients may be an indicator of retinopathy. Further research should be carried out to confirm these findings.
Keywords: malondialdehyde, superoxide dismutase, diabetic retinopathy
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