Original Research Article
Year: 2019 | Month: September | Volume: 6 | Issue: 9 | Pages: 353-358
A Quantitative Analysis of Treatment Failure Criteria Laid Down by NACO for Suspected Failures of First Line HAART
Dr. Sabhavathu Vijaya 1, Dr. Kethavath Sunil Naik 2, Dr. Kiran Anaparthi 3
1Associate Professor, Dept. of Pharmacology, Government Medical College, Srikakulam.
2Associate Professor, Dept. of General Medicine, Government Medical College, Srikakulam.
3Civil Assistant Surgeon, Primary Health Centre, Gottipadu, Guntur.
Corresponding Author: Dr. Kethavath Sunil Naik
ABSTRACT
A rising trend of HIV in new pockets within the country and gradual reduction from high incident states has got attention for consideration of new aspect in HIV treatment, Third line medication. Before starting to implement third line medication, we wanted to analyse the existing criteria for suspected failures and assess for its effectiveness in identification of failures. Out of 3 criteria, we took 2 criteria which can be easily assessed from available date. For the study, we have included all PLHIV who are on treatment for at least 2 years, with criteria 1 to be latest CD4 less than baseline CD4 and criteria 2 to be latest CD4 less than 100 cells/ml. As per study, criterion 1, Latest CD4 <100, 147 patients at 3.01% were identified as failure and as per criterion 2, Latest CD4<Baseline CD4,1128 patients were identified as failures at 23.11% So, the second criteria made it easy for paramedical staff to identify failures more efficiently. The success rate has climbed to 26.13% when both the criterions were used.
Overall failure identified was 1155 failures. Herewith, we deduced that implementation of criteria 2 alone, which is simple to identify, can give maximum number of failures at an early stage of treatment but overall, collective implementation of all criteria can possibly identify maximum possible failures. The failures identified with 2 or more criteria should be given much importance to start in second line HAART to reduce considerable chances of reduced IRIS and to improve living chances for PLHIV with second line medication and further improves chances for use of third line in future and same criteria needed for identification of second line failures also.
Key words: Treatment failure, HAART, Second line treatment, third line treatment, IRIS
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