Original Research Article
Year: 2019 | Month: August | Volume: 6 | Issue: 8 | Pages: 340-346
Evaluation of Anti-Inflammatory and Antipyretic Effect of Aqueous Extract of Tinospora Cordifolia in Rats
Dr. Sumanlata1, Dr. Akanksha Suman2, Dr. Rajeev Kumar Sharma3, Dr. Adnan Khan4
1Professor and Head, 2Associate Professor, 3,4Professor,
Department of Pharamacology, Muzaffarnagar Medical College, Muzaffarnagar, Uttar Pradesh.
Corresponding Author: Dr. Akanksha Suman
ABSTRACT
Non Steroidal anti-inflammatory drugs (NSAIDs) are the mainstay for the treatment of inflammation and pyrexia. These drugs are synthetic in nature and are associated with many adverse effects which effect compliance of patients. Plants are used since ages as natural resources of medicines to treat various ailments. Tinospora cordifolia is widely available and its use is mentioned in various literatures. In the present study the aqueous extract of stem of T. cordifolia in graded doses (1.25g/kg, 2.5g/kg and 5gm/kg) was used to evaluate the anti-inflammatory activity by carrageenan and histamine induced rat paw edema and anti-pyretic activity by Brewer’s yeast induced pyrexia model in albino rats. The statistical analysis showed significant anti-inflammatory and anti-pyretic activity comparable to that of standard drugs Diclofenac sodium and Paracetamol respectively. Present study showed the potential of T cordifolia as future anti-inflammatory and anti-pyretic drugs. This activity may be attributed to the presence of various phytoconstituents present in extract of T.cordifolia.
Key words: T.cordifolia, Anti-inflammatory, Anti-pyretic, Aqueous extract, Carrageenan, Histamine, Brewer’s yeast.
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