Original Research Article
Year: 2019 | Month: August | Volume: 6 | Issue: 8 | Pages: 16-20
Comparative Study of Using Intrathecal Clonidine and Fentanyl as an Adjuvant to Hyperbaric Bupivacaine (0.5%) in Lower Abdomen Surgeries
Suman Kaushik
Associate Professor, Department of Anaesthesia, Ananta Institute of Medical Sciences, Rajsamand
ABSTRACT
Objective: The present study was carried out to compare the effect of intrathecal Clonidine and intrathecal Fentanyl as an adjuvant to hyperbaric Bupivacaine in terms if efficacy, safety and post-operative analgesia in patients undergoing lower abdominal surgeries.
Material and methods: 100 patients planned for elective lower abdominal surgery under spinal anaesthesia were included in present study. The patients were divided into two groups viz. group I (n=50) in which patients were given 2.5 ml of hyperbaric Bupivacaine (0.5%) with 50µg of Clonidine intrathecally and group II (n=50) in which patients were given 2.5 ml of hyperbaric Bupivacaine (0.5%) with 25µg of Fentanyl intrathecally. Assessment was done in terms of time taken for onset of sensory and motor blockade, duration of sensory and motor blockade and requirement of rescue analgesia.
Results: Patients’ age, height, weight, sex ratio, mean arterial pressure during surgery (MAP), heart rate (HR) and duration of surgery were not significantly different between two groups. Onset of sensory blockade was significantly lower in Fentanyl group (group II) (2.02±0.15 min) while onset of motor blockade was significantly lower in Clonidine group (group I) (4.62±1.21 min). Duration of sensory and motor blockade was significantly less in Fentanyl group. Time for requirement of first dose of analgesia was also significantly longer in clonidine group (490.55±28.98 min) when compared to fentanyl group (421.19±26.64 min).
Conclusion: addition of 50µg Clonidine to hyperbaric Bupivacaine as an adjuvant in spinal anaesthesia for lower abdominal surgeries offers longer post-operative analgesia than Fentanyl with no side effects.
Key words: Clonidine, Bupivacaine, Spinal, Fentanyl, abdominal surgery
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