Original Research Article
Year: 2019 | Month: July | Volume: 6 | Issue: 7 | Pages: 40-44
Serum and Salivary C - reactive protein In Patients with Oral Leukoplakia and Squamous Cell Carcinoma
Dr Sonia Gupta1, Dr. Nutan Tyagi2, Dr. Afreen Nadaf3
1Tutor, Department of Oral Pathology and Microbiology, Govt. Dental College and Hospital Srinagar.
2Reader, Department of Oral Pathology and Microbiology, Institute of Dental Studies and Technologies, Kadrabad, Modinagar, (U.P.)
3Lecture, Department of Oral Pathology and Microbiology, Govt. Dental College and Hospital Srinagar.
Corresponding Author: Dr Sonia Gupta
ABSTRACT
Aims and objective: To determine the levels of serum and salivary C-reactive protein in patients with oral leukoplakia and squamous cell carcinoma as well as to evaluate their significant role as a prognostic marker.
Materials and method: The study sample consisted of 30 patients and the subjects were divided into three groups. Group A included 10cases of normal oral mucosa, Group B comprised 10 cases of oral leukoplakia and Group C included 10 cases of OSCC confirmed by histopathological examination. Salivary and serum levels of CRP were determined using immunoturbidimetry based on agglutination.
Results: The mean serum and salivary level of CRP in OSCC was more as compared to oral leukoplakia and normal oral mucosa. The p-value was found to be statistically significant
Conclusion: CRP is a biomarker which can be used for the evaluation of the severity of the disease.
Key words: Biomarkers, Leukoplakia, Oral Cancer, C-reactive protein
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