Original Research Article
Year: 2019 | Month: November | Volume: 6 | Issue: 11 | Pages: 225-230
To Determine the Prognostic Value of C - Reactive Protein (CRP) and Tumor Necrosis Factor (TNF)-α as Predictors of Systemic Complications in Acute Pancreatitis
Dr. Nitika Khanna1, Dr. Rati Mathur2, Dr. Shyam Sunder Sharma3
1PhD Scholar, 2Senior Professor,
Dept. of Biochemistry, SMS Medical College and Attached group of Hospitals, Jaipur (Rajasthan)
3Senior Professor and Head, Dept. of Gastroenterology, SMS Medical College and Attached group of Hospitals, Jaipur (Rajasthan)
Corresponding Author: Dr. Rati Mathur
ABSTRACT
Background: Early assessment of severity in acute pancreatitis (AP) is a key measure to provide rational and effective management.
Aim: of this study is to determine the prognostic value of C - reactive protein (CRP) and Tumor Necrosis Factor (TNF)-α as predictors of systemic complications in AP.
Materials and Methods: total 210 patients with confirmed AP were enrolled in the study. The severity of AP was defined according to Atlanta criteria. Measurements of CRP and TNF-α were performed on the 1st day and on 3rd day of admission.
Results: on day 1st & day 3rd serum levels of CRP found highly significantly different (p < 0.000) between the severe group and the mild group and TNF-α was found higher (p < 0.05) in the severe group than in mild cases on day 1st only. On day 1and day 3, CRP had a higher sensitivity (83.3%, 78.6%) and accuracy (80%, 75.8%) compared with TNF-α showed low level of sensitivity and diagnostic accuracy on both the days.
Conclusion: our study confirmed that by determining the serum concentration of CRP on the 3rd day of admission represents a valuable diagnostic tool in the assessment of severity and course of disease in patients with acute pancreatitis.
Key words: acute pancreatitis; CRP; systemic complications; TNF-α
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