Original Research Article
Year: 2019 | Month: November | Volume: 6 | Issue: 11 | Pages: 209-213
Evaluation of Antiulcer Activity by Using Flower Extract of Ctenolepis Garcini in Aspirin Induced Rats
Dr. Challa Pradeep Kumar, Dr. Penchala Prathap, Dr. Munawwar Husain Kazmi, Amala Darshanala
Department of Pharmacology, Vaageswari College of Pharmacy, Karimanagar, 505001, India.
Corresponding Author: Amala Darshanala
ABSTRACT
Peptic ulcer is a hole in the gut lining of the stomach, duodenum, or esophagus. An ulcer occurs when the lining of these organs is corroded by the acidic digestive juices that are secreted by the stomach cell. The objective of the present study is to evaluate the effects of plant extracts of ctenolepis garcini whole plant on gastric ulcer
Methodology: the study is conducted with 16 animals divided into four groups of four each at random. All drugs were administered orally. The first group served as a control and was administered vehicle only, second group served as a positive control and were treated with standard drug ranitidine. Third and fourth group served as test groups. Drugs and vehicle were administered 30 minutes before the administration of aspirin. Ulcer induction is observed with aspirin after six hours. When all rats were killed by using anesthetic ether and their stomachs dissected out. The parameters taken to assess volume of gastric secretion, pH, free acidity, total acidity and ulcer index were estimated in the aspirin induced gastric ulcers in albino rats.
Key words: ctenolepis garcini, peptic ulcer.
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