Year: 2026 | Month: May | Volume: 13 | Issue: 5 | Pages: 693-698
DOI: https://doi.org/10.52403/ijrr.20260567
Vitiligo Onset in Older Age Post Folfox Chemotherapy in a Colon Carcinoma Patient: Case Report
Ummu Aiman1, Densy Violina Harnanti1, Efenina Ginting2, Febelia Devina Setyadarma3, Aulia Aiman4
1School of Medicine, Universitas Hang Tuah Surabaya, Indonesia
1Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
2Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
3Faculty of Medicine, Universitas Katolik Widya Mandala Surabaya, Indonesia
4Faculty of Medicine, Universitas Udayana, Indonesia
Corresponding Author: Ummu Aiman
ABSTRACT
Vitiligo is a pigmentation disorder characterized by the progressive loss of melanocytes, leading to distinct depigmented macules. Vitiligo with onset at an older age is relatively rare, especially when it appears after chemotherapy. We report a case of generalized vitiligo in a 74-year-old female patient with a history of colon carcinoma who received a Folfox chemotherapy regimen (5-fluorouracil, leucovorin, oxaliplatin). Depigmented lesions commenced following the third treatment round and progressively enlarged. The diagnosis was established based on characteristic clinical features without additional examinations due to limited facilities. The patient was treated with 5% liquor carbonis detergens (LCD) combined with topical corticosteroids, showing a good initial clinical response. This case report highlights the potential association between FOLFOX chemotherapy and the development of late-onset vitiligo, as well as the importance of clinical diagnosis in daily practice.
Keywords: vitiligo, chemotherapy, folfox, colon carcinoma
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