Year: 2026 | Month: April | Volume: 13 | Issue: 4 | Pages: 526-533
DOI: https://doi.org/10.52403/ijrr.20260453
Hematological and Biochemical Effects of the Aqueous Extract of the Phytotherapeutic Formulation Zigarda in Balb/c Mice
Archange Michel Emmanuel MBOUNGOU MALONGA1,2, Alice NZAMBI PASSI spouse MATETE MOUNOI1, Syrlie Marina OSSEKE1,3, Landry Martial MIGUEL1, Ange Antoine ABENA1,4
1Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Congo
2WTScL, Community, Brazzaville, Congo
3Brazzaville University Hospital, Brazzaville, Republic of Congo
4Denis SASSOU NGUESSO University, Brazzaville, Congo
Corresponding Author: Archange Michel Emmanuel MBOUNGOU MALONGA
ABSTRACT
Background: Zigarda is a phytotherapeutic formulation composed of three plants with multiple recognized medicinal properties.
Objective: To evaluate its effects on hematological and biochemical parameters in Balb/c mice.
Methods: Eighteen mice were divided into three groups: control (distilled water), Zigarda 200 mg/kg, and Zigarda 400 mg/kg, administered orally for 30 days. Body weight, hematological and biochemical parameters were monitored.
Results: Our results showed a slight increase in weight and a highly significant (p<0.001) stimulation of leukocytes, suggesting an immunostimulatory effect. A significant decrease (p<0.05) in red blood cells and platelets was observed, as well as a significant increase (p<0.05) in liver enzymes, which may indicate a potential risk to the liver. Lipidemia showed a biphasic effect, with significant hypolipidemic potential (p<0.05).
Conclusion: The phytotherapeutic formulation Zigarda has therapeutic benefits, particularly immunostimulatory and metabolic.
Keywords: Zigarda, Immunostimulation, Lipid-lowering effect, Balb/c mice.
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