Year: 2025 | Month: May | Volume: 12 | Issue: 5 | Pages: 583-590
DOI: https://doi.org/10.52403/ijrr.20250560
Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Elderly Inpatients: A Retrospective Study at Dr. M. Djamil Padang Hospital (2016-2022)
Afifah Nabila1, Satya Wydya Yenny2, Firdawati3, Ennesta Asri2, Dessy Arisanty4, Elfira Yusri5
1Faculty of Medicine, Andalas University, Padang, West Sumatera, Indonesia
2Department of Dermatology and Venereology, Andalas University, Padang, West Sumatera, Indonesia
3Departement of Public Health and Community Medicine, Andalas University, Padang, West Sumatera, Indonesia
4Departement of Biochemistry, Andalas University, Padang, West Sumatera, Indonesia
5Departement of Clinical Pathology, Andalas University, Padang, West Sumatera, Indonesia
Corresponding Author: Afifah Nabila
ABSTRACT
Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are acute mucocutaneous conditions primarily triggered by medications and associated with high morbidity and mortality, especially among the elderly. This retrospective descriptive study was conducted to evaluate the clinical profile of elderly inpatients diagnosed with SJS and TEN at Dr. M. Djamil Hospital, Padang from 2016 to 2022. A total of 29 medical records were analyzed. The mean patient age was 64.9 years, with a slight male predominance (51.7%). Hypertension was the most common comorbidity (34.5%). Most cases presented with epidermolysis affecting less than 10% of body surface area (62.1%). All cases were drug-induced, with antibiotics for 41.4% of the causes. All patients exhibited the classic triad of mucocutaneous involvement. A majority of patients were hospitalized for ≤10 days (75.9%), and the SCORTEN score of 2 was most frequently observed (44.8%), predicting a 12.1% mortality risk. The recovery rate was 82.8%, while mortality reached 17.2%, predominantly due to septic complications. Findings highlight the need for cautious prescribing, early diagnosis, and prompt supportive treatment in elderly patients with SJS/TEN.
Keywords: elderly, Stevens Johnson Syndrome, Toxic Epidermal Necrolysis
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