Year: 2025 | Month: April | Volume: 12 | Issue: 4 | Pages: 327-339
DOI: https://doi.org/10.52403/ijrr.20250440
The Association between Long-Term Vitamin D Supplementation and Increased Risk of Nephrolithiasis in Adults: A Problem-Based Critical Review
Millati Samha Arrasuli1, Krisadelfa Sutanto1
1Department of Nutrition, Faculty of Medicine, University of Indonesia - Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia
Corresponding Author: Millati Samha Arrasuli
ABSTRACT
Background: Nephrolithiasis has high recurrence and causes a decrease in the patients’ quality of life. One of the hallmarks of the disease is hypercalciuria. Vitamin D is known to have a role in calcium homeostasis and can increase risk of hypercalciuria. To date, not many studies have looked at the association between long-term (≥ 1 year) vitamin D supplementation in adult patients with the increased risk of nephrolithiasis and many of the available study results are still inconsistent and thus, inconclusive, due to a great variability in treatments duration and daily dose of vitamin D supplementation.
Objective: To investigate the association between long-term (≥ 1 year) vitamin D supplementation of 2000 IU/day with the increased risk of nephrolithiasis in adult patients.
Method: This study used literature search on Pubmed, Cochrane Library, and EMBASE through suitability with the clinical question and eligibility criteria determined by the authors.
Results: Based on the critical review of 6 literatures comprising 2 SR/MA, 2 RCTs and 2 prospective cohorts, the study concluded that there is no increased risk of nephrolithiasis in adults taking long-term (≥ 1 year) vitamin D supplementation of 2000 IU/day.
Conclusion: Long-term (≥ 1 year) vitamin D supplementation of 2000 IU/day in adult patients does not increase the risk of nephrolithiasis.
Keywords: Vitamin D, ergocalciferol, cholecalciferol, supplementation, supplementation, nephrolithiasis, kidney stones, renal calculi.
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