Original Research Article
Year: 2023 | Month: June | Volume: 10 | Issue: 6 | Pages: 432-438
DOI: https://doi.org/10.52403/ijrr.20230655
Comparison of Platelet-to-Lymphocyte Ratio at Different COVID -19 Severity in Adam Malik Hospital, Medan, Indonesia
Retno Nurul Mandasari1, Dairion Gatot2, Heny Syahrini Lubis3
1Department of Internal Medicine, Medical Faculty, North Sumatra University, Indonesia, 2Haematology and
Oncology Division, Department of Internal Medicine, Medical Faculty, North Sumatra University, Indonesia
Corresponding Author: Retno Nurul Mandasari
ABSTRACT
Introduction. Several inflammatory indicators such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphopenia have shown an inflammatory response of COVID-19. Nevertheless, not much research has been done in Indonesia. This study aims to determine the difference between PLR and severity of COVID-19 disease in Adam Malik Hospital, Medan.
Method. A retrospective study was conducted from September 2020 to February 2021 to analyze the medical records of patients with confirmed COVID-19. Patients' clinical severity was categorized according to the criteria of WHO. PLR is calculated by dividing the platelet count by the lymphocyte count obtained from a complete blood count of a COVID-19 patient at the time of hospital admission. A comparative analysis was performed to determine differences in PLR at different clinical severities of COVID-19.
Results. A total of 114 patients were enrolled in the study. Most of the COVID-19 patients are patients with non-severe grade, 57.1%, while the other 42.9% are patients with severe grade. In both severity grades, the platelet count is basically normal, while a low lymphocyte count is observed in the severe severity grades. Higher PLR values were found in severe COVID -19 patients, with a significant difference between severe and non-severe patients (p=0.00).
Conclusion. There is a significant difference in PLR in severe and non-severe COVID -19 grades.
Keywords: Platelet-to-lymphocyte Ratio, Severity, COVID-19, Inflammation
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