Original Research Article
Year: 2023 | Month: May | Volume: 10 | Issue: 5 | Pages: 354-359
DOI: https://doi.org/10.52403/ijrr.20230542
The Relationship Between Platelet Lymphocyte Ratio (PLR) with Depressed Level in Patients with Chronic Kidney Disease (CKD) Undergoing Regular Hemodialysis at Haji Adam Malik General Hospital Medan
Wika Hanida Lubis
Division of Psychosomatic, Department of Internal Medicine, Faculty of Medicine University of North
ABSTRACT
Background: Inflammation and stress levels associated with Chronic Kidney Disease (CKD) can lead to poor quality of life and adverse medical outcomes. Currently, the commonly used inflammatory tests in CKD patients are C-reactive protein (CRP), procalcitonin (PCT), and ferritin. Nonetheless, these tests have some drawbacks, such as being less specific, expensive, and difficult to access. Therefore, the platelet-lymphocyte ratio (PLR) can be considered as a promising alternative as a prognostic indicator in CKD patients with major depression.
Methods: This research is an analytical study with a cross-sectional design carried out in February 2023 until the number of samples is fulfilled, at the Hemodialysis Installation of RSUP. H. Adam Malik to analyze the relationship of PLR in depressed patients with CKD undergoing regular hemodialysis. The data analysis used is the Pearson correlation test if the data is normally distributed. If the data is not normally distributed, Spearman's correlation test is performed. Statistical analysis used a 95% confidence level (p<0.05).
Results: In this study, the demographic characteristics of 86 patients were obtained with a mean age of 49.08 years with a standard deviation of 14.11. Based on the Spearman rho test, it was found that there was no significant correlation between the PLR score and the BDI II score with a p value of 0.975. The r value is 0.003. This shows that there is a very weak correlation between the PLR score and the BD II score.
Conclusion: There is no correlation between Depression level and Platelet Lymphocyte Ratio (PLR) in CKD patients undergoing regular hemodialysis.
Keywords: Depression, Platelet Lymphocyte Ratio (PLR), chronic kidney disease (CKD), Inflammation
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