Original Research Article
Year: 2017 | Month: July | Volume: 4 | Issue: 7 | Pages: 76-79
Age-Specific Reference Range for Prostate Specific Antigen: A Retrospective Analysis in North Indian Population
Richa Goel1, Himanshu Devender Kumar2, Ashuma Sachdeva3, Veena Singh Ghalaut4, Asha Kumari5
1Senior Resident, Department of Biochemistry, 2Junior Resident, Department of Medicine,
Maharishi Markandeshwar Institute of Medical Sciences and Research, Mullana, Haryana, India 133207
3Professor, 4Professor and Head, 5Senior Resident,
Department of Biochemistry, Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana 124001
Corresponding Author: Himanshu Devender Kumar
ABSTRACT
Studies have attempted to establish age-specific reference range for Serum Prostate Specific Antigen (PSA) levels, to enhance its sensitivity and specificity as a marker for prostate cancer. Biopsy, acknowledged as the gold standard diagnostic tool for prostate cancer, holds the demerits of being invasive procedure. Our study was directed to find a correlation between TPSA with age and to establish its appropriate reference range for evaluation of men at risk for early detection of potentially curable prostate cancer to avoid unnecessary biopsies. Retrospective data of serum PSA levels was analyzed in 1077 men aged between 40-90 years with no diagnostically positive prostate cancer, and whose PSA values were obtained as a part of clinical work up of symptoms related to non-malignant urological conditions, during the period of 2010-11. Serum PSA was estimated by solid-phase, competitive chemiluminescent immunoassay using standard kits. There was a continuous increase in mean and median of PSA, with a significant correlation (p<0.05), with advancing age. It also implies that serum PSA correlates with age, primarily due to increasing prostate volume as age advances.
Key words: Total Prostate Specific Antigen, Prostate Cancer, Reference Range, Chemiluminescence
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