Original Research Article
Year: 2017 | Month: July | Volume: 4 | Issue: 7 | Pages: 1-8
Thyroid Dysfunction in a Rural Region of North Kerala, India-Its Association with Dyslipidemia and Diabetes Mellitus
Sangeetha V Joice1, Rebecca Abraham1, Dinesh Kumar2, Beena Kumari1
1Department of Biochemistry, Malabar Medical College & Research Centre, Calicut, Kerala PINCODE-673315
2Department of Psychiatry, Malabar Medical College & Research Centre, Calicut, Kerala PINCODE- 673315
Corresponding Author: Rebecca Abraham
ABSTRACT
The principle aim of our study was (i) to assess the thyroid status of this region and (ii) to study the relationship of thyroid dysfunction with Dyslipidemia and Diabetes Mellitus. Thyroid dysfunction was seen in 10.6% of the total 650 subjects with hypothyroidism in 8.6% subjects and hyperthyroidism in 2%. 46% of subjects with hyperthyroidism were in the age group 35-44 years and 32% with hypothyroidism in the age group 45-54 years. A higher percentage of women was both hypothyroid (13.2%) and hyperthyroid (2.3%) (p=0.000). 58% of women with hypothyroidism were in the age group 45-64 years and men in the age group 45-54 years. The majority of men with hyperthyroidism (50%) and women (57%) were in the age group 35-44 years. No significant association between TSH levels and economic status, diet and life style was observed. The total cholesterol levels were higher in the hypothyroid group whereas the LDL cholesterol was slightly increased in the hyperthyroid group. Women had higher serum total cholesterol levels across all three thyroid states as compared to men.12.5% of hypothyroids and 24.2% of hyperthyroids had associated diabetes mellitus. Hypothyroidism is predominantly present, principally amongst women in this region and in the age group 45-64 years. Associated dyslipidemia and diabetes mellitus was also higher in this group. Early screening and treatment can help prevent possible cardiovascular outcomes.
Key words: thyroid dysfunction, dyslipidemia, diabetes mellitus
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